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Construction of metalloenzymes: coordination chemistry and catalytic activities in proteins

Release time:2018-02-06 12:43Clicks:

Topic:Construction of metalloenzymes: coordination chemistry and catalytic activities in proteins

Speaker:Prpf. Yoshihito Watanabe

Abstract:Based on catalytic reactions, coordination chemistry, and organometallic chemistry, we are able to design enzymes which catalyze nobel reactions such as oxidation, hydrogenation, C-C coupling, and polymerization.

Keywords: Catalytic Chemistry, Metal Complex, Organometallic Chemistry, Mutation, Oxidation, Reduction, Suzuki Coupling,polystyrene, Myoglobin, Heme Enzyme, Ferritin

Major Experience:
1972 - 1976 B.Sc. Tohoku University
1977 - 1982 Dr. Sc. Tsukuba University
1982 Postdoctoral Fellow, University Michigan
1985 Res. Staff Member, Princeton University, Princeton, NJ, USA
1987 Assistant Professor, School of Medicine, Keio University
1990 Associate Professor, Kyoto University
1994 Professor, Institute for Molecular Science
2002 - present Professor, Nagoya University
2009 - present vice-President, Nagoya University

Research Field
Bioinorganic Chemistry, Enzymatic Reaction Mechanism, Biological Oxidation Chemistry

Selected Publications
• Y. Watanabe et al. "Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes," Angew. Chem. Int. Ed., 53, 2862–2866 (2014).
• Y. Watanabe et al. "Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules," Angew. Chem. Int. Ed., 52, 6606-6610 (2013).
• Y. Watanabe et al. “Crystal Structure of H2O2-Dependent Cytochrome P450SPα with its Bound Fatty Acid Substrate: Insight into the regioselective hydroxylation of fatty Acids at the α Position,” J. Biol. Chem., 286, 29941-29950 (2011).
• Y. Watanabe et al. "Reactivities of Oxo and peroxo Intermediates Studied by Hemoprotein Mutants," Acc. Chem. Res., 40, 554-562 (2007).

Event Date: Sep 15,2016(Thursday)
Event Time:3:00pm
Venue: Conference Hall 2nd Floor, Inorganic Supramolecular Building